Clinically Proven Effects of Naticol® Collagen

Collagen is the most abundant protein in the human body and is the key to the firmness and elasticity of skin, hair, and nails. After our 25th year of life, collagen production naturally declines, resulting in a thinner epidermis, reduced hydration, and the formation of wrinkles.

More and more consumers are choosing to supplement in the form of a supplement to counteract the visible signs of skin aging and support the natural regeneration process. Naticol® is a patented type I fish collagen peptide that has been investigated in numerous clinical studies for efficacy and safety.

Naticol® in Plent Beauty Care products

At Plent Beauty Care, we use Naticol® hydrolyzed fish collagen peptides in our products. In this article, we explain—based on research findings on Naticol® collagen—why we use this type of collagen.

What makes Naticol® unique?

Naticol® fish collagen is sourced from sustainably caught fish and undergoes enzymatic hydrolysis, resulting in short peptides with a low molecular weight (< 4 kDa). This ensures high bioavailability: the peptides are rapidly and efficiently absorbed into the bloodstream and distributed to the skin and other tissues.

The characteristic Naticol® hydrolyzed fish collagen peptides contribute to:

• Skin hydration (through an increase in water-binding capacity)
• Elasticity (improved structure and resilience)
• Wrinkle reduction (restoration of the dermal matrix)
• Overall skin quality, including radiance and a more even complexion¹

¹ See www.naticol.com/en/ (consulted July 2025).

Clinical studies with Naticol® collagen

Several studies have been conducted on the effects of Naticol® collagen at various dosages:

Clinical study Naticol® collagen: dosage 2.5 g/day

In a double‑blind, randomized, placebo‑controlled trial (CSP 3507), 95 healthy women (avg. 55.6 years) received 2.5 g of Naticol® or a placebo daily for 12 weeks. The key findings were:

• Wrinkle reduction: After 12 weeks, > 70 % of participants showed a clear reduction in crow’s feet and > 60 % an improvement in perioral wrinkles.* 
• Elasticity: A significant increase in the skin’s pure elasticity (R1), measured with the Cutometer® SEM 575.*
• Radiance & complexion: Significant improvement in skin radiance and evenness from week 8, assessed by trained clinicians using VAS.*
• Tolerance: Excellent tolerability, with no serious adverse events reported.*

*Source: Naticol study PDF 2.5g

Clinical study Naticol® collagen: dosage 5 g/day

In a study (CSR 3463) of 60 women (avg. 56 years) who took 5 g of Naticol® or a placebo daily for 8 weeks, the following effects were observed:

• Reduction in wrinkle depth: A significant decrease in the clinical score for periorbital wrinkles (–11 % vs. baseline) after 8 weeks.*
• Firmness: A significant reduction in total skin extensibility (Uf), indicating increased skin firmness on both the abdomen and face.*
• Hydration under cold conditions: Indications that Naticol® can counteract cold-induced dehydration, based on improved biomechanical parameters.*
• Tolerance: Good tolerability with no notable adverse events.*

*Source: Naticol study PDF 5g

Clinical study Naticol® collagen: dosage 10 g/day

A larger study (CP 3407) with 40 women (50–70 years) investigated the effect of 10 g of Naticol® per day for 12 weeks:

• Hydration: An increase in skin hydration of +22.8 % after 6 weeks and maintained at 12 weeks, measured with the Corneometer CM 825.*
• Elasticity & extensibility: Improvements in stretchability (+23.7 %) and a decrease in rebound factor, indicating higher elasticity.*
• Wrinkle reduction: Significant reduction in wrinkles compared to placebo after 12 weeks (p < 0.05).*
• Acceptance & tolerance: Excellent taste acceptance and tolerability, with no serious adverse events.*

*Source: Naticol study PDF 10g

Scientific Rationale and Regulation

When communicating about collagen dietary supplements, it is essential to comply with European Regulation (EC) 1924/2006 and Dutch NVWA guidelines. Only approved claims may be used, such as:

Vitamin C:

• Contributes to normal collagen formation for the skin*
• Contributes to the formation of collagen that helps strengthen the skin from within*
• Contributes to the maintenance of normal skin*
• Helps protect cells from oxidative damage*
• Contributes to the maintenance of healthy cells and tissues*
• Helps reduce tiredness and fatigue*
• Acts as an antioxidant for vitamin E and restores it to an active form*
• Supports concentration and memory*

Zinc:

• Good for hair, skin, and nails*
• Contributes to the maintenance of healthy cells and tissues*
• Contributes to the maintenance of normal structure and function of the skin*

Copper:

• Contributes to normal pigmentation of skin and hair*
• Helps keep the skin’s connective tissue supple*
• Helps protect healthy cells and tissues*

Manganese:

• Contributes to normal connective tissue formation*
• Has an antioxidant function*
• Supports the maintenance of healthy cells and tissues*

Thiamine (vitamin B1):

• Supports energy levels*
• Helps release energy from food*
• Supports normal heart function*

Riboflavin (vitamin B2):

• Contributes to the maintenance of normal skin*
• Contributes to the protection of cells from oxidative damage*
• Helps nourish the skin from within*

Niacin (vitamin B3):

• Contributes to the maintenance of normal skin*
• Supports energy levels*
• Helps nourish the skin from within*

Pantothenic Acid (vitamin B5):

• Supports energy metabolism*
• Contributes to normal resistance to stress*
• Provides support in case of fatigue*

Vitamin B6:

• Contributes to the regulation of hormonal activity*
• Supports the immune system*
• Positively influences the metabolism of proteins and carbohydrates*

Biotin (vitamin B8):

• Contributes to the maintenance of normal hair and skin*
• Supports normal fat metabolism*
• Supports the maintenance of healthy skin*

Folate (vitamin B11):

• Contributes to the process of cell renewal*
• Plays a role in tissue growth and development*

Vitamin B12:

• Supports the formation of cells and tissues*
• Contributes to a normally functioning immune system*
• Contributes to normal psychological function*

*Health claims approved by the European Commission when consumed in sufficient quantities.

Conclusion

The scientific evidence consistently shows that daily intake of Naticol® fish collagen peptides positively affects skin hydration, elasticity, and wrinkle formation at dosages starting from 2.5 g. Higher dosages (5 g and 10 g) provide additional benefits in firmness and hydration.

Thanks to its high bioavailability and excellent tolerability, Naticol® is a safe and effective choice for consumers looking to support their skin, hair, and nails.

Our product lines Pure Marine Collagen and Beauty Blend Collagen combine Naticol® with carefully selected vitamins and minerals.